Diffusion tensor imaging in a rat model of Parkinson's disease after lesioning of the nigrostriatal tract
Identifieur interne : 000087 ( France/Analysis ); précédent : 000086; suivant : 000088Diffusion tensor imaging in a rat model of Parkinson's disease after lesioning of the nigrostriatal tract
Auteurs : Nadja Van Camp [Belgique, France] ; Ines Blockx [Belgique] ; Marleen Verhoye [Belgique] ; Cindy Casteels [Belgique] ; Frea Coun [Belgique] ; Alexander Leemans [Royaume-Uni, Pays-Bas] ; Jan Sijbers [Belgique] ; Veerle Baekelandt [Belgique] ; Koen Van Laere [Belgique] ; Annemie Van Der Linden [Belgique]Source :
- NMR in Biomedicine [ 0952-3480 ] ; 2009-08.
English descriptors
- KwdEn :
Abstract
Parkinson's disease (PD) is characterised by degeneration of the nigrostrial connection causing dramatic changes in the dopaminergic pathway underlying clinical pathology. Till now, no MRI tools were available to follow up any specific PD‐related neurodegeneration. However, recently, diffusion tensor imaging (DTI) has received considerable attention as a new and potential in vivo diagnostic tool for various neurodegenerative diseases. To assess this in PD, we performed DTI in the acute 6‐hydroxydopamine (6‐OHDA) rat model of PD to evaluate diffusion properties in the degenerating nigrostriatal pathway and its connecting structures. Injection of a neurotoxin in the striatum causes retrograde neurodegeneration of the nigrostriatal tract, and selective degeneration of nigral neurons. The advantage of this model is that the lesion size is well controllable by the injected dose of the toxin. The degree of functional impairment was evaluated in vivo using the amphetamine rotation test and µPET imaging of the dopamine transporter (DAT). Despite a nearly complete lesion of the nigrostriatal tract, DTI changes were limited to the ipsilateral substantia nigra (SN). In this study we demonstrate, using voxel‐based statistics (VBS), an increase in fractional anisotropy (FA), whereas all eigenvalues were significantly decreased. VBS enabled us to visualise neurodegeneration of a cluster of neurons but failed to detect degeneration of more diffuse microstructures such as the nigrostriatal fibres or the dopaminergic endings in the striatum. VBS without a priori information proved to be better than manual segmentation of brain structures as it does not suffer from volume averaging and is not susceptible to erroneous segmentations of brain regions that show very little contrast on MRI images such as SN. Copyright © 2009 John Wiley & Sons, Ltd.
Url:
DOI: 10.1002/nbm.1381
Affiliations:
- Belgique, France, Pays-Bas, Royaume-Uni
- Province d'Anvers, Utrecht (province), Île-de-France
- Anvers, Orsay, Utrecht
- Université d'Anvers
Links toward previous steps (curation, corpus...)
- to stream Main, to step Corpus: 000D04
- to stream Main, to step Curation: 000B48
- to stream Main, to step Exploration: 000B15
- to stream France, to step Extraction: 000087
Links to Exploration step
ISTEX:E5C66EB71369FC9AE2C30D95DBA381175DB6E0FALe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Diffusion tensor imaging in a rat model of Parkinson's disease after lesioning of the nigrostriatal tract</title><author><name sortKey="Van Camp, Nadja" sort="Van Camp, Nadja" uniqKey="Van Camp N" first="Nadja" last="Van Camp">Nadja Van Camp</name></author><author><name sortKey="Blockx, Ines" sort="Blockx, Ines" uniqKey="Blockx I" first="Ines" last="Blockx">Ines Blockx</name></author><author><name sortKey="Verhoye, Marleen" sort="Verhoye, Marleen" uniqKey="Verhoye M" first="Marleen" last="Verhoye">Marleen Verhoye</name></author><author><name sortKey="Casteels, Cindy" sort="Casteels, Cindy" uniqKey="Casteels C" first="Cindy" last="Casteels">Cindy Casteels</name></author><author><name sortKey="Coun, Frea" sort="Coun, Frea" uniqKey="Coun F" first="Frea" last="Coun">Frea Coun</name></author><author><name sortKey="Leemans, Alexander" sort="Leemans, Alexander" uniqKey="Leemans A" first="Alexander" last="Leemans">Alexander Leemans</name></author><author><name sortKey="Sijbers, Jan" sort="Sijbers, Jan" uniqKey="Sijbers J" first="Jan" last="Sijbers">Jan Sijbers</name></author><author><name sortKey="Baekelandt, Veerle" sort="Baekelandt, Veerle" uniqKey="Baekelandt V" first="Veerle" last="Baekelandt">Veerle Baekelandt</name></author><author><name sortKey="Van Laere, Koen" sort="Van Laere, Koen" uniqKey="Van Laere K" first="Koen" last="Van Laere">Koen Van Laere</name></author><author><name sortKey="Van Der Linden, Annemie" sort="Van Der Linden, Annemie" uniqKey="Van Der Linden A" first="Annemie" last="Van Der Linden">Annemie Van Der Linden</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:E5C66EB71369FC9AE2C30D95DBA381175DB6E0FA</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1002/nbm.1381</idno><idno type="url">https://api.istex.fr/document/E5C66EB71369FC9AE2C30D95DBA381175DB6E0FA/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000D04</idno><idno type="wicri:Area/Main/Curation">000B48</idno><idno type="wicri:Area/Main/Exploration">000B15</idno><idno type="wicri:Area/France/Extraction">000087</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Diffusion tensor imaging in a rat model of Parkinson's disease after lesioning of the nigrostriatal tract</title><author><name sortKey="Van Camp, Nadja" sort="Van Camp, Nadja" uniqKey="Van Camp N" first="Nadja" last="Van Camp">Nadja Van Camp</name><affiliation wicri:level="4"><country xml:lang="fr">Belgique</country><wicri:regionArea>Bio‐Imaging Laboratory, University of Antwerp, Antwerp</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>CEA, Institut d'Imagerie BioMédicale, Service Hospitalier Frédéric Joliot, Orsay</wicri:regionArea><placeName><region type="région" nuts="2">Île-de-France</region><settlement type="city">Orsay</settlement></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U803, Orsay</wicri:regionArea><placeName><region type="région" nuts="2">Île-de-France</region><settlement type="city">Orsay</settlement></placeName></affiliation></author><author><name sortKey="Blockx, Ines" sort="Blockx, Ines" uniqKey="Blockx I" first="Ines" last="Blockx">Ines Blockx</name><affiliation wicri:level="4"><country xml:lang="fr">Belgique</country><wicri:regionArea>Bio‐Imaging Laboratory, University of Antwerp, Antwerp</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation></author><author><name sortKey="Verhoye, Marleen" sort="Verhoye, Marleen" uniqKey="Verhoye M" first="Marleen" last="Verhoye">Marleen Verhoye</name><affiliation wicri:level="4"><country xml:lang="fr">Belgique</country><wicri:regionArea>Bio‐Imaging Laboratory, University of Antwerp, Antwerp</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Belgique</country><wicri:regionArea>Vision Laboratory, University of Antwerp, Antwerp</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation></author><author><name sortKey="Casteels, Cindy" sort="Casteels, Cindy" uniqKey="Casteels C" first="Cindy" last="Casteels">Cindy Casteels</name><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Division of Nuclear Medicine, University Hospital Gasthuisberg and K.U. Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Coun, Frea" sort="Coun, Frea" uniqKey="Coun F" first="Frea" last="Coun">Frea Coun</name><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory for Neurobiology and Gene Therapy, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Leemans, Alexander" sort="Leemans, Alexander" uniqKey="Leemans A" first="Alexander" last="Leemans">Alexander Leemans</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff</wicri:regionArea><wicri:noRegion>Cardiff</wicri:noRegion></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Image Sciences Institute, Dept. Radiology, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Sijbers, Jan" sort="Sijbers, Jan" uniqKey="Sijbers J" first="Jan" last="Sijbers">Jan Sijbers</name><affiliation wicri:level="4"><country xml:lang="fr">Belgique</country><wicri:regionArea>Vision Laboratory, University of Antwerp, Antwerp</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation></author><author><name sortKey="Baekelandt, Veerle" sort="Baekelandt, Veerle" uniqKey="Baekelandt V" first="Veerle" last="Baekelandt">Veerle Baekelandt</name><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory for Neurobiology and Gene Therapy, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Van Laere, Koen" sort="Van Laere, Koen" uniqKey="Van Laere K" first="Koen" last="Van Laere">Koen Van Laere</name><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Division of Nuclear Medicine, University Hospital Gasthuisberg and K.U. Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Van Der Linden, Annemie" sort="Van Der Linden, Annemie" uniqKey="Van Der Linden A" first="Annemie" last="Van Der Linden">Annemie Van Der Linden</name><affiliation wicri:level="4"><country xml:lang="fr">Belgique</country><wicri:regionArea>Bio‐Imaging Laboratory, University of Antwerp, Antwerp</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">NMR in Biomedicine</title><title level="j" type="sub">An International Journal Devoted to the Development and Application of Magnetic Resonance In vivo</title><title level="j" type="abbrev">NMR Biomed.</title><idno type="ISSN">0952-3480</idno><idno type="eISSN">1099-1492</idno><imprint><publisher>John Wiley & Sons, Ltd.</publisher><pubPlace>Chichester, UK</pubPlace><date type="published" when="2009-08">2009-08</date><biblScope unit="volume">22</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="697">697</biblScope><biblScope unit="page" to="706">706</biblScope></imprint><idno type="ISSN">0952-3480</idno></series><idno type="istex">E5C66EB71369FC9AE2C30D95DBA381175DB6E0FA</idno><idno type="DOI">10.1002/nbm.1381</idno><idno type="ArticleID">NBM1381</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0952-3480</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>6‐OHDA rat model</term><term>DTI</term><term>Parkinson's disease</term><term>neurodegeneration</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parkinson's disease (PD) is characterised by degeneration of the nigrostrial connection causing dramatic changes in the dopaminergic pathway underlying clinical pathology. Till now, no MRI tools were available to follow up any specific PD‐related neurodegeneration. However, recently, diffusion tensor imaging (DTI) has received considerable attention as a new and potential in vivo diagnostic tool for various neurodegenerative diseases. To assess this in PD, we performed DTI in the acute 6‐hydroxydopamine (6‐OHDA) rat model of PD to evaluate diffusion properties in the degenerating nigrostriatal pathway and its connecting structures. Injection of a neurotoxin in the striatum causes retrograde neurodegeneration of the nigrostriatal tract, and selective degeneration of nigral neurons. The advantage of this model is that the lesion size is well controllable by the injected dose of the toxin. The degree of functional impairment was evaluated in vivo using the amphetamine rotation test and µPET imaging of the dopamine transporter (DAT). Despite a nearly complete lesion of the nigrostriatal tract, DTI changes were limited to the ipsilateral substantia nigra (SN). In this study we demonstrate, using voxel‐based statistics (VBS), an increase in fractional anisotropy (FA), whereas all eigenvalues were significantly decreased. VBS enabled us to visualise neurodegeneration of a cluster of neurons but failed to detect degeneration of more diffuse microstructures such as the nigrostriatal fibres or the dopaminergic endings in the striatum. VBS without a priori information proved to be better than manual segmentation of brain structures as it does not suffer from volume averaging and is not susceptible to erroneous segmentations of brain regions that show very little contrast on MRI images such as SN. Copyright © 2009 John Wiley & Sons, Ltd.</div></front></TEI><affiliations><list><country><li>Belgique</li><li>France</li><li>Pays-Bas</li><li>Royaume-Uni</li></country><region><li>Province d'Anvers</li><li>Utrecht (province)</li><li>Île-de-France</li></region><settlement><li>Anvers</li><li>Orsay</li><li>Utrecht</li></settlement><orgName><li>Université d'Anvers</li></orgName></list><tree><country name="Belgique"><region name="Province d'Anvers"><name sortKey="Van Camp, Nadja" sort="Van Camp, Nadja" uniqKey="Van Camp N" first="Nadja" last="Van Camp">Nadja Van Camp</name></region><name sortKey="Baekelandt, Veerle" sort="Baekelandt, Veerle" uniqKey="Baekelandt V" first="Veerle" last="Baekelandt">Veerle Baekelandt</name><name sortKey="Blockx, Ines" sort="Blockx, Ines" uniqKey="Blockx I" first="Ines" last="Blockx">Ines Blockx</name><name sortKey="Casteels, Cindy" sort="Casteels, Cindy" uniqKey="Casteels C" first="Cindy" last="Casteels">Cindy Casteels</name><name sortKey="Coun, Frea" sort="Coun, Frea" uniqKey="Coun F" first="Frea" last="Coun">Frea Coun</name><name sortKey="Sijbers, Jan" sort="Sijbers, Jan" uniqKey="Sijbers J" first="Jan" last="Sijbers">Jan Sijbers</name><name sortKey="Van Der Linden, Annemie" sort="Van Der Linden, Annemie" uniqKey="Van Der Linden A" first="Annemie" last="Van Der Linden">Annemie Van Der Linden</name><name sortKey="Van Laere, Koen" sort="Van Laere, Koen" uniqKey="Van Laere K" first="Koen" last="Van Laere">Koen Van Laere</name><name sortKey="Verhoye, Marleen" sort="Verhoye, Marleen" uniqKey="Verhoye M" first="Marleen" last="Verhoye">Marleen Verhoye</name><name sortKey="Verhoye, Marleen" sort="Verhoye, Marleen" uniqKey="Verhoye M" first="Marleen" last="Verhoye">Marleen Verhoye</name></country><country name="France"><region name="Île-de-France"><name sortKey="Van Camp, Nadja" sort="Van Camp, Nadja" uniqKey="Van Camp N" first="Nadja" last="Van Camp">Nadja Van Camp</name></region><name sortKey="Van Camp, Nadja" sort="Van Camp, Nadja" uniqKey="Van Camp N" first="Nadja" last="Van Camp">Nadja Van Camp</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Leemans, Alexander" sort="Leemans, Alexander" uniqKey="Leemans A" first="Alexander" last="Leemans">Alexander Leemans</name></noRegion></country><country name="Pays-Bas"><region name="Utrecht (province)"><name sortKey="Leemans, Alexander" sort="Leemans, Alexander" uniqKey="Leemans A" first="Alexander" last="Leemans">Alexander Leemans</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/France/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000087 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000087 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= France
|étape= Analysis
|type= RBID
|clé= ISTEX:E5C66EB71369FC9AE2C30D95DBA381175DB6E0FA
|texte= Diffusion tensor imaging in a rat model of Parkinson's disease after lesioning of the nigrostriatal tract
}}
| This area was generated with Dilib version V0.6.23. |  |